Protein kinase C pharmacology: refining the toolbox
نویسندگان
چکیده
منابع مشابه
Protein kinase C pharmacology: refining the toolbox.
PKC (protein kinase C) has been in the limelight since the discovery three decades ago that it acts as a major receptor for the tumour-promoting phorbol esters. Phorbol esters, with their potent ability to activate two of the three classes of PKC isoenzymes, have remained the best pharmacological tool for directly modulating PKC activity. However, with the discovery of other phorbol ester-respo...
متن کاملPreclinical pharmacology of the natural product anticancer agent bryostatin 1, an activator of protein kinase C.
Bryostatin 1, a natural product anticancer agent isolated from a marine bryozoan, has been shown in tissue culture to activate protein kinase C. This agent has recently undergone Phase I testing in humans given either as a bolus i.v. injection or a continuous infusion. To understand how bryostatin 1 might be used best as an anticancer agent, a study of the pharmacokinetics, tissue distribution,...
متن کاملThe Implication of Androgens in the Presence of Protein Kinase C to Repair Alzheimer’s Disease-Induced Cognitive Dysfunction
Aging, as a major risk factor of memory deficiency, affects neural signaling pathways in hippocampus. In particular, age-dependent androgens deficiency causes cognitive impairments. Several enzymes like protein kinase C (PKC) are involved in memory deficiency. Indeed, PKC regulatory process mediates α-secretase activation to cleave APP in β-amyloid cascade and tau proteins phosphorylation mecha...
متن کاملOverexpression of Protein Kinase C - C Stimulates
A function for protein kinase C(PKC), a member of the phorbol ester nonresponsive atypical protein kinase C subfamily, in modulating differentiation was examined in the leukemic U937 cell. Transfected U937 cells stably overexpressing PKCdisplayed a longer doubling time, lower saturation density at confluency, and an increase in adherence to plastic as compared to control cells. PKCcells express...
متن کاملAGC protein kinase phosphorylation and protein kinase C.
Protein kinase cascades feature in many signal transduction pathways. For those discussed here, a single upstream protein kinase appears to be responsible for the control of multiple downstream targets. So how is specificity introduced into these events? For the downstream kinases (substrates) described here, it would appear that specificity is determined by substrate-directed events that are p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochemical Journal
سال: 2013
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj20130220